When the next pandemic occurs, the impact of the disease and our response to it will join the lexicon of nation-changing incidents like Hurricane Katrina and the September11 attacks. The magnitude of this episode will divide forever the progress of our nation between its pre-pandemic and post-pandemic history. It is very difficult with all of the pressures on budgets, time, and resources to respond to a threat that has not yet manifested itself, but some threats are just too great to ignore. Given the potential impact of a pandemic on our nation, we must begin our preparation efforts now.The strategy outlined in this report states that the pandemic threat requires "the leveraging of all instruments of national power, and coordinated action by all segments of government and society." Governors and lead state officials should prepare for the emerging threat of avian influenza and the possibility of a subsequent pandemic influenza episode.