Governors are in a unique position to streamline safety net efforts by strengthening cross-system collaboration to serve vulnerable populations. There are incredible opportunities for state and local partners to create cross-jurisdictional relationships to provide unified fronts on certain issues—such as homelessness and housing instability—that are tailored to meet the unique needs of their communities. Addressing the housing needs of low-income families is an opportunity for governors to lead the way in identifying innovations in public service with federal, county, local, and private sector partners. Supportive housing is an evidence-based solution that pairs subsidized housing with coordinated support services to stabilize the most vulnerable. This model has demonstrated reductions in use of shelter, and child welfare and criminal justice system involvement, and other safety net services. Drawing on insights from a convening of gubernatorial policy advisors, Addressing Housing Instability Through Systems Alignment and Coordination is a brief from CSH and NGA that highlights examples from some of the many states that are turning to data-driven supportive housing models that embrace systems alignment, coordination and partnerships to address housing instability.